#003-ACTIVINa In Stock
For research Purposes Only. Not for use in diagnostic or therapeutic procedures.
Activin-A is a TGF-beta family member that exhibits a wide range of biological activities including regulation of cellular proliferation and differentiation, and promotion of neuronal survival. Elevated levels of Activin-A in human colorectal tumors and in post-menopausal woman have been implicated in colorectal and breast cancers, respectively. The biological activities of Activin-A can be neutralized by inhibins and by the diffusible TGF-beta antagonist, Follistatin. Human Activin-A is a 26 kDa disulfide-linked homodimer of two beta A chains, each containing 116 amino acid residues.
Reconstitution: We recommend a quick spin followed by reconstitution in water to a concentration of 50 μg/ml (e.g., 5 μg/100μl) will yield a solution of 10 mM Citric Acid, pH 3.0.
Storage: This solution can then be stored at room temperature or at 4°C for 1 month. It is recommended that further dilutions be made in PBS containing 2 mg/ml albumin and stored at -20°C.
| Properties | |
|---|---|
| Species | Human, Rat, Mouse |
| Expression System | High-5, Insect Cells |
| Molecular Weight | 26 kDa |
| Full Length | 118 Amino Acids |
| Purity | ≥ 95% by SDS-PAGE and HPLC Analyses |
| Tag | No Tag |
| Form | Lyophilized |
| Endotoxin |
<1 EU/µg |
| Activity |
The ED50 was determined by its ability to inhibit the murine MPC-11 cells. The expected ED50 is 0.5 - 2.0 ng/ml. |
| Storage |
-20°C |